Endocrine Abstracts

It is suggested that phosphatidylinositol 3-kinase pathway is involved in regulation of estrogen effects in the uterus. Therefore, effects of posphatidylinositol 3-kinase blocker, wortmannin, on proliferative and morphogenetic reactions in the uterus under long-term estrogen treatment were examined. Ovariectomized mice were treated with estradiol dipropionate (4 μg per 100 g; s.c.; once a week) or vehicle and wortmannin (0.1 mg per 100 g; s.c.; once a day) or vehicle for ...